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These data illustrate how the enzymatic action of GPx-1 links it to the intracellular GSH/GSSG redox couple transferring redox stress in the cell to the easily restored GSSG rather than reactive protein thiols (189, 196)

PubMed, Barcelos, Gustavo Rafael Mazzaron, et al

After all, it has already been established that delivering glutathione to the inside of the cell is vitally important because glutathione performs all its important roles as our master antioxidant inside the cell, not outside

Additionally, establishment of detailed optimal drug administration conditions for GGCT and xCT inhibitors will be an important step, although further research is required to advance this strategy

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