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It would be interesting to determine whether intranasal delivery of mRNA vaccines can promote T RM cells and protection in the lung

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[DOI] [PMC free article] [PubMed] [Google Scholar] 181.Stracke H, Gaus W, Achenbach U, Federlin K & Bretzel RG Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study

At the 12 mg dose level, here is what clinical trials reported: Nausea: 43.2% of participants (versus 10.7% on placebo) Diarrhea: 33.1% of participants (versus 13.4% on placebo) Constipation: 25.0% of participants (versus 8.7% on placebo) Vomiting: 20.9% of participants These percentages tell an important story