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SIRT3 was shown to deacetylate mouse mitochondrial 2-oxoglutarate carrier SLC25A11 on K73 in the brain ( C

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(2006) Predicting benefit from anti-angiogenic agents in malignancy

There was even a theory originally put out in the 1950s called The Free Radical Theory of Aging* which basically held that we age by rusting from within, due largely (but not exclusively) to free radical damage