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In terms of iron metabolism and homeostasis in immune cells, a study revealed that iron overload promotes abnormal differentiation of pathogenic T cells, including follicular helper T cells, by regulating DNA demethylation, thus exacerbating autoantibody production and the development of systemic lupus erythematosus (SLE) [26]

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Cell death pathway inhibition The role of cell death pathways in mediating 8803 efficacy was evaluated via pharmacologic inhibition

Clinically significant fluid retention could theoretically alter the volume of distribution of apixaban, though no study has quantified this effect

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Liu, L

PMID: 9005976