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The only way to know for sure, Hur said, is with more research

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For example, three of these compounds cyclopenta[ c,d ]pyrene, dibenzo[ a,l ]pyrene, and dibenz[ a,h ]anthracene have been evaluated by the International Agency for Research on Cancer as probably carcinogenic to humans (Group 2A) based on a combination of carcinogenicity studies in laboratory animals and mechanistic data

CONCLUSIONS Our findings support a model in which cigarette smoke exposure is associated with MKK3/p38 MAPK activation and PRKN Ser131 phosphorylation, accompanied by impaired PRKN-dependent mitophagy and increased epithelial senescence markers in vitro and in vivo

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