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We discuss drug mechanism of action and pharmacokinetic disposition relevant to the development of peripheral neuropathy, the epidemiology and clinical presentation of chemotherapy-induced neuropathy, emerging insight into genetic susceptibilities as well as current understanding of the pathophysiology and treatment approaches

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For example, NMT1 inhibition inactivates the mTOR signaling pathway in bladder cancer by modulating the localization and stability of the late endosomal/lysosomal adaptor, MAPK, and mTOR activator 1 (LAMTOR1)