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Regueiro et al., 2023)

Early research shows that MOTS-c may improve insulin sensitivity, support fat loss, boost exercise capacity, reduce inflammation, and help slow age-related muscle loss

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Mechanistically, GCN5L1 inhibits ERK activation by reducing mitochondrial ROS production, leading to increased FOXO1 levels, which induce the expression of the gluconeogenic enzyme PEPCK and glucose 6-phosphatase (G6Pase)

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