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However, trials of single antioxidant supplements for extending lifespan in humans have largely been disappointing

(2004) Analysis of transcription factor expression during discrete stages of postnatal thymocyte differentiation J

Mutant TDP-43 activates M1 microglia and upregulates pro-inflammatory mediators NOX2, TNF-, and IL-1 (Beers et al., 2012

doi: 10.1038/nn.3144

The research also noted that these effects occurred without the hypoglycemia sometimes saw with insulin or native IGF-1, suggesting a more favorable safety profile for research uses