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These activities apply stress to the skeletal system, promoting bone strength and reducing age-related bone mass loss

Musso T, Gusella GL, Brooks A, Longo DL, Varesio L

The HLA-DR genes undergo posttranscriptional modifications under inflammatory conditions, leading to the production of autoantibodies known as rheumatoid factors (RFs) in susceptible individuals, a phenomenon not observed in healthy individuals

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[1] It is caused by the presence of mutations in both copies (alleles) of the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein