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Rather than trying to force a peptide through the gastrointestinal barrier using formulation technology, several research groups asked whether a small, non-peptide molecule could be designed to activate the GLP-1 receptor directly

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Semaglutide increases insulin secretion and reduces glucagon release

"Adipocyte apoptosis: a novel target for obesity therapy." Experimental & Molecular Medicine 52 (2020): 1039-1051

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