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Glutathione S -transferase-P1 expression correlates with increased antioxidant capacity in transitional cell carcinoma of the urinary bladder

Then, 5,10-methyleneTHF acts as a methyl-donor for thymidylate synthase (TS) to synthesize deoxythymidine monophosphate (dTMP) from deoxyuracil monophosphate (dUMP) or for methylenetetrahydrofolate reductase (MTHFR) to generate 5-mTHF [31] (Figure 1)