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Also, intermittent PPI therapy has been shown to reduce the total amount of PPI used, which may reduce long-term side effects, although this has not been firmly established (Laine 2016)

Secondary flavoproteome defects associated with mitochondrial dysfunction Primary Mitochondrial Disorders Acyl-CoA dehydrogenase-9 deficiency (ACAD9) (OMIM #611126) Acyl-CoA dehydrogenase 9 (ACAD9), a mitochondrial protein, was initially demonstrated to catalyze the initial rate-limiting step in the beta-oxidation of long-chain fatty acids [48]

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