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REST directly binds to the promoter region of glutamate-cysteine ligase (GCLM), inhibits the synthesis of GSH through transcriptional inhibition of GCLM expression, and induces ferroptosis
Both in vitro and in vivo experiments confirmed that restoring levels of glutathione in PD patients represents a promising strategy to slow down the progression of the disease (Pradhan et al
LiQZhangZShiWLiZXiaoYZhangJet al
J Natl Cancer Inst 106(3):djt456
Thnh phn: 500 mg L-glutathione (reduced)
Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease , vol
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