acido alfa lipoico y l carnitina Ácido acetil-L-carnitina alfa-lipoico, 120 cápsulas Acetil L-Carnitina HCL y Ácido

What Are the Ongoing Research Directions

F.KatayamaT.OsadaS.UmesonoK.NamuraS

Abbreviations 2-BP: 2-bromopalmitate 2-DG: 2-deoxy-D-glucose 2HG: 2-hydroxyglutarate 3-BP: 3-Bromopyruvate 5-FU: 5-fluorouracil 53BP1: P53-binding protein 1 -KG: -ketoglutarate ACLY: ATP-citrate lyase ALDH: Aldehyde dehydrogenase ATM: Ataxia telangiectasia mutated ATR: Ataxia telangiectasia and Rad3-related BCNU: 1,3-bis(2-chloroethyl)-1-nitrosourea BRCA1/2: Breast cancer type 1/2 susceptibility protein CBP: CREB-binding protein CIN: Chromosomal instability DDR: DNA damage response DFMO: Difluoromethylornithine DHFR: Dihydrofolate reductase DHODH: Dihydroorotate dehydrogenase DHS: Trans-4,4-dihydroxystilbene DNPH1: 2-deoxynucleoside 5-phosphate N-hydrolase 1 DOT1L: Disruptor of telomeric silencing 1-like DSBs: Double-strand breaks DSF: Disulfiram EGFR: Epidermal growth factor receptor ER: Estrogen receptor F1,6P: Fructose-1,6-bisphosphate FA: Fanconi anemia FAO: Fatty acid oxidation FH: Fumarate hydratase FINs: Ferroptosis inducers G6PD: Glucose-6-phosphate dehydrogenase GBM: Glioblastoma GCN5: General control non-derepressible 5 GDP-M: Guanosine diphosphatemannose Glo1: Glyoxalase 1 GLUT1: Glucose transporter 1 GPX4: Glutathione peroxidase 4 GR: Glutathione reductase Grx: Glutaredoxin GSH: Glutathione H3K9: Histone 3 lysine 9 HDAC: Histone deacetylase HK2: Hexokinase 2 hmdUMP: 5-hydroxymethyl-deoxyuridine monophosphate HMGB1: High mobility group box 1 HNE: 4-hydroxy-2-nonenal HR: Homologous recombination IDH: Isocitrate dehydrogenase IMPDH: Inosine monophosphate dehydrogenase LDH: Lactate dehydrogenase LPO: Lipid peroxidation MDA: Malondialdehyde MG: Methylglyoxal MMR: Mismatch repair MRN: MRE11-RAD50-NBS1 complex MSI: Microsatellite instability NADK: NAD+ kinase NAMPT: Nicotinamide phosphoribosyltransferase NHEJ: Non-homologous end joining NIN: Nucleotide instability NRF2: Nuclear factor erythroid 2-related factor 2 NSCLC: Non-small cell lung cancer ODC: Ornithine decarboxylase OGT: O-GlcNAc transferase OXPHOS: Oxidative phosphorylation PARP: Poly(ADP-ribose) polymerase PFK2: Phosphofructokinase-2 PKM2: Pyruvate kinase muscle 2 isoform PPP: Pentose phosphate pathway PRMT: Protein arginine methyltransferase PTMs: Post-translational modifications R5P: Ribose-5-phosphate RNR: Ribonucleotide reductase ROS: Reactive oxygen species RPA: Replication protein A RRM2: Ribonucleotide reductase M2 SDH: Succinate dehydrogenase SLC7A11: Solute carrier family 7 member 11 SSBs: Single-strand breaks TCA: Tricarboxylic acid TIP60: Tat-interactive protein 60 kDa TKT: Transketolase TNBC: Triple-negative breast cancer Trx: Thioredoxin TrxR: Thioredoxin reductase TS: Thymidylate synthase References Faubert B, Solmonson A, DeBerardinis RJ

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Li, Z., Barnes, J

References [1] Detcheverry F, Senthil S, Narayanan S, Badhwar A