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While observational studies consistently link selenium deficiency to worse outcomes, randomized clinical trials have shown inconsistent results, especially concerning mortality reduction and ICU length of stay

Notably, regulation of T cell differentiation was enriched in hypermethylated CpG sites, aligning with studies demonstrating the involvement of ketamine in the inhibition of the differentiation and reactivation pathogenic Th17 cells, which is upregulated in patients with MDD [81, 82]