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Timelapse imaging revealed no significant changes in the 405/488 fluorescence ratio in the nucleoli during the cell cycle ( Figure 3d )

However, we cannot assume that all CAT enzymes localised to various subcellular regions are functionally active

The mechanism is compelling

doi: 10.1016/j.jprot.2022.104683, PMID: [DOI] [PubMed] [Google Scholar] 405

Therapeutic potential of PEGylated insulin-like growth factor I for skeletal muscle disease evaluated in two murine models of muscular dystrophy

With proper standardization and dosing, many natural metabolites appear to cause fewer severe side effects than some synthetic drugs (though vigilance is still required, as any bioactive substance can pose risks at high doses or in susceptible individuals)