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N-acetylcysteine (NAC), a precursor of reduced glutathione (GSH), has been widely used as an antioxidant against reactive oxygen species (ROS) in several disorders related to oxidative stress [8], in addition to its applications in ischemiareperfusion injury, acute respiratory distress syndrome and chemotherapy-induced toxicity [13,14,15], NAC has also been proposed as an anticancer agent in vitro and in vivo either stand-alone or as an adjuvant to reduce aggressiveness in several cancers [16, 17]

MSR and SN revised and edited the manuscript

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Original file (396 396 pixels, file size: 2 KB, MIME type: image/png) File information Structured data Captions Structures with stereochemistry

Hiddemann W, Buechner T, Andreeff M , Woermann B, Arlin Z, Clarkson BD

Hemoglobin spectrophotometry data were recorded using a spectrophotometer program SPECS SSP-715-M (Spectroscopic systems LTD, Moscow, Russia)