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This theory matches data from the German prospective multicenter study ALLIVE including 22 MDS and 90 AML patients and some smaller studies, which show an increase in NTBI and LIP levels during allogeneic HSCT ( During the course of AML, signs of iron overload have also been described

Ramsammy, S., Morlok, J., Ramsammy, L., Addiss, D.A., and Macpherson, C.N.L

In contrast, decreasing [GSH]i with BSO sensitized cells to peroxide toxicity

Interestingly, several consensus sites for PAD have been identified in RG/RGG motifs

A square planar environment around the metal center plays an important role in binding the superoxide radical anion at the metal center

Ziegler L Article: METABOLISM-CLINICAL AND EXPERIMENTAL