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This requires the p53 transcriptional target cyclin-dependent kinase inhibitor 1A (encoding p21) and is associated with slower depletion of intracellular glutathione and decrease accumulation of toxic lipid-ROS (143)

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980,981 A Phase 3, multicenter, randomized trial (EudraCT 2012-000353-31, NCT01825512) compared the efficacy of DFX and DFP in pediatric patients with transfusion-dependent haemoglobinopathies and found that DFP was more effective and safer in controlling iron overload than DFX over a 12-month treatment period

Thus, effects of dietary calcium inadequacy would primarily result in negative effects to bone health