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doi: 10.1586/1744666X.2015.1037286 10 JangJHShinHWLeeJMLeeHWKimECParkSH

296,297 Clinical evidence suggests SAMe may be helpful in treating depression, including in people with elevated homocysteine levels

The decreased mitochondrial potential results in the deregulation of fuel and energy requirements and in poor functioning of mitochondria, which play a role in the integration of cellular decisions concerning death, survival, and immune activation, such as the activation of macrophages and their microbicidal abilities (Wagener et al., 2014)