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10.3389/fimmu.2011.00035 [DOI] [PMC free article] [PubMed] [Google Scholar] 175

Firstly, it can cause direct damage to a plethora of cellular iron-containing targets (including the enzyme aconitase and mitochondrial electron-transport complexes carrying FeS clusters)

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7.3.6 Clinical translation Successful translation of ferroptosis-targeted therapies requires methodical progression through several key stages: validation of candidate biomarkers in well-characterized human cohorts, optimization of inhalation formulations for consistent pulmonary deposition, and demonstration of safety and efficacy through rigorously designed clinical trials