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Intermediate cells in the TME (e.g., endothelial cells, TAMs) express high levels of IDO and TDO, leading to tryptophan depletion, which inhibits T cell proliferation and function, causing cell cycle arrest at the G1 phase

Neuroscience 79 , 4556 (1997)

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FeSN demonstrated a remarkably high level of POD-like activity, with theoretical calculations and enzymatic reaction kinetics indicating that its catalytic efficiency was around thirty times greater than that of FeS 2