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Dihexa (PNB-0408) is a synthetically derived Angiotensin IV analog that is blood-brain barrier permeable, stable, and orally bioavailable [1]

2015;10:e0118784

Daugan M, Dufay Wojcicki A, d'Hayer B, Boudy V

41 In addition to these agents, amycretina dual GLP-1 and amylin RAis currently under investigation for chronic weight management

Not a substitute for proper medical care, but potentially a useful adjunct

At these doses, the hepatic pathway overlap with dulaglutide's metabolism and the independent hepatic enzyme signals from each agent create a monitoring obligation