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Moreover, rapamycin upregulated Wnt/-catenin signaling, including statistically significant upregulation of the T cell memory genes TCF7, LEF1, FOXO1 in rapamycin-treated products (Supplementary Data 5b)

Currently, most studies of the role of epigenetic mechanisms in OLG function, including proliferation, have been carried out in animal models, with only limited studies in human OPCs/OLGs

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