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This is followed by the addition of glycine to the C-terminus of gamma-glutamylcysteine via the enzyme GSH synthetase to form GSH

doi: 10.3390/biom12111622

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If Grx(SSR) intermediates and mixed disulfides with roGFP2 were more stable and were readily formed, glutaredoxins would sense and transfer a plethora of other redox states to roGFP2 probes

Since it has been previously reported that in endothelial cells (ECs), eNOS activation can be induced via Ca-dependent dimerization and Akt-dependent phosphorylation, ultimately enhancing NO production and vascular function [71], we sought to investigate whether a similar mechanism is involved in our model

Discovery of a potent glutathione peroxidase 4 inhibitor as a selective ferroptosis inducer