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These mechanisms have been substantiated in animal model studies

The diversity of proteins which interact with NQO1 has grown significantly and recent work demonstrated stabilization of HIF-1 by NQO1 in RKO colon tumors in mice xenografts as a result of impaired proteasomal degradation (Oh et al., 2016)

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Claudins are a group of proteins with molecular weights ranging from 21 to 34 kDa (6870)